https://repositorio.ufpb.br/jspui/handle/123456789/2334 2026-04-09T07:13:03Z 2026-04-09T07:13:03Z LIMA, WENDERSON RENOVATO DE https://repositorio.ufpb.br/jspui/handle/123456789/35375 2025-07-31T06:08:14Z 2024-12-06T00:00:00Z

Título: Valeriana officinalis: PROPRIEDADES FARMACOLÓGICAS, APLICAÇÕES E SUAS INTERAÇÕES Autor(es): LIMA, WENDERSON RENOVATO DE Orientador: Santos, Roberto Mendes dos Abstract: The present thesis aims to investigate the pharmacological properties, applications, and interactions of the plant Valeriana officinalis, widely used in traditional medicine for the treatment of sleep-related disorders and anxiety. The research was structured into four main stages: choosing the guiding question, literature search, data collection and analysis, and discussion of the results. The central question formulated was: “What is the general overview of studies on Valeriana officinalis and its drug interactions?”. The literature review was conducted through the CAPES virtual library, using descriptors in Health Sciences. A total of 790 studies were identified, of which 14 were selected after reading titles and abstracts, resulting in 10 eligible articles and 3 additional from gray literature. The results indicate that most studies are reviews, with an emphasis on experimental investigations. The analysis of the collected data allowed for the identification of various therapeutic properties of Valeriana officinalis, as well as its interactions with other medications. This work contributes to the understanding of the therapeutic potential of the plant and its implications in clinical practice, highlighting the importance of further research to elucidate its properties and safety in use. Editor: Universidade Federal da Paraíba Tipo: TCC

2024-12-06T00:00:00Z DUTRA, ZENNO COSTA https://repositorio.ufpb.br/jspui/handle/123456789/35374 2025-07-31T06:08:13Z 2024-12-06T00:00:00Z

Título: PERFIL EPIDEMIOLÓGICO E DE MORTALIDADE EM INTERNAÇÕES POR DENGUE NO ESTADO DA PARAÍBA ENTRE OS ANOS DE 2014 A 2023 Autor(es): DUTRA, ZENNO COSTA Orientador: Fernandes, Ana Isabel Vieira Abstract: Introduction: Dengue isaninfectiousdiseasetransmittedbythe Aedes Aegypti mosquito, whichhas 4 serotypes (DENV-1, DENV-2, DENV-3 and DENV-4), withpresentationsrangingfrommildfeverto dengue hemorrhagicfeverandshock. Climatechangeandurbanizationinfluence its occurrence, characterizing it as a global publichealth problem. In Brazil, transmissionisheterogeneousandsuffersfromunderreporting. Therefore, thisstudyanalyzesthe dengue mortality profile in Paraíba from 2014 to 2023, usingepidemiological data tounderstandriskfactors, trends andcollaboratewiththepromotionofpreventionstrategies, aimingto improve publichealthandqualityoflife.Methods:Thisis a descriptive, cross-sectionalstudywith a quantitative approach, whichanalyzestheepidemiological profile and dengue mortality in Paraíba between 2014 and 2023. The data wascollected online from SIH/SUS via DATASUS andanalyzedusingdescriptivestatistics, organizingvariablessuch as age group, gender, race/color, andhospitalizationandmortality rates in tablesandgraphsusing Excel.Results: Dengue hospitalizations in Paraíba reached more expressivevalues in 2016, in additiontoimportantfluctuations over theyears. Most hospitalizationsoccurredbetween May andJune, while deaths were more common between April and May. The behaviorofhospitalizationsand deaths variedaccordingto age groupandgender, withhospitalizationsbeingpredominantly male and deaths female, especiallyafterthe age of 30.Conclusions: The studyconcludesthattheincrease in dengue hospitalizations in Paraíba follows nationaloutbreaks, significantlyimpactingpublichealth. Women, brownpeople, children, adolescentsandtheelderly are more vulnerable, highlightingtheimportanceofreachingthispublic in preventionand management strategies. The territorial analysisshowedtheinfluenceofsocioeconomicandclimaticfactorsontheincidenceofthedisease, whilepresentinglimitations for evaluation, whilethe Covid-19 pandemicaffectednotificationsandresources, reinforcingtheimportanceofcontinuouscontrolandvaccinationtomitigatetheburdenonthehealth system. Editor: Universidade Federal da Paraíba Tipo: TCC

2024-12-06T00:00:00Z DELGADO, VÍTOR MEDEIROS https://repositorio.ufpb.br/jspui/handle/123456789/35372 2025-07-31T06:08:14Z 2024-11-03T00:00:00Z

Título: REDUÇÃO DO METABOLISMO CEREBRAL REGIONAL EM PACIENTES COM FIBRILAÇÃO ATRIAL SEM ACIDENTE VASCULAR CEREBRAL: Insights de um estudo FDG-PET Autor(es): DELGADO, VÍTOR MEDEIROS Orientador: Targueta, Gabriel Pelegrineti Abstract: Background and aims Atrial Fibrillation (AF) is an independent risk factor for incident dementia. Cerebral hypoperfusion related to beat-to-beat blood flow variation during AF can explain the occurrence of dementia or mild cognitive impairment in stroke-free AF patients. However, brain metabolism patterns in this scenario are still uncertain. We aimed to investigate brain metabolism patterns in stroke-free AF patients under optimal oral anticoagulation treatment. Methods Ten patients with long-standing persistent/permanent AF underwent brain FDG-PET imaging. Images from patients, controls without AF or dementia (n=28), and Alzheimer Disease (AD) patients (n=28), were compared. Cognitive questionnaires were applied. 24h-Holter and Echocardiogram were also performed. Exclusion criteria: paroxysmal AF, presence of permanent pacemaker, previous diagnosis of stroke or dementia, hemodynamically relevant carotid stenosis, moderate/severe aortic valve stenosis, psychiatric disorder, decompensated diabetes, previous neurosurgery, alcoholism, or presence of left ventricular systolic dysfunction. FDG-PET images were compared using statistical parametric mapping to assess regional brain metabolism differences between the groups. Results The study group median age was 64, 70% male. The median CHA2DS2VASC score was 1 and 90% of the patients were taking oral anticoagulants. All patients had normal ejection fractions (median 65%) and well controlled heart rate on Holter (mean 75bpm). Fronto-temporal cerebral hypometabolism was observed in study patients compared to controls. This hypometabolism pattern was distinct from AD patients’ pattern, which was more pronounced in components of the limbic system. Conclusion AF patients present a specific pattern of brain hypometabolism, independent of the occurrence of thromboembolic phenomena and distinct from the AD pattern. Editor: Universidade Federal da Paraíba Tipo: TCC

2024-11-03T00:00:00Z ARAGÃO, TAINÁ GOMES https://repositorio.ufpb.br/jspui/handle/123456789/35371 2025-07-31T06:08:10Z 2024-10-30T00:00:00Z

Título: AVALIAÇÃO DO PERFIL SOCIOECONÔMICO DE CRIANÇAS PORTADORAS DE FISSURAS LABIOPALATINAS EM SERVIÇO DE REFERÊNCIA Autor(es): ARAGÃO, TAINÁ GOMES Orientador: Maia, Rayana Elias Abstract: Objective: This study aims to evaluate the socioeconomic profile of children with clefts in a population assisted at a referral hospital in the state of Paraíba. Methodology: This is a cross-sectional, observational, analytical, retrospective, and quantitative study conducted between September 2022 and August 2023. The research was carried out at the Cleft Lip and Palate Service of the Lauro Wanderley University Hospital (HULW), linked to the Federal University of Paraíba (UFPB). Data were analyzed using SPSS software version 24.0. Nonparametric tests (Mann-Whitney U, Kruskal-Wallis H) and Spearman's rho correlation coefficient were applied. The significance level adopted was 5%, and the confidence interval was 95%. Results: The study included 79 caregivers of children with cleft lip (18.2%), cleft palate (23.4%), and cleft lip and palate (58.4%). Regarding the socioeconomic profile, 42.7% of the families had an income of up to 1 minimum wage, and 45.3% had an income of between 1 and 3 minimum wages. It was observed that 80.5% of the pregnancies were desired, 60.3% were planned, and the use of folic acid and ferrous sulfate was reported by 84.6% of the pregnant women. Regarding knowledge of risk factors, 58.2% were aware of environmental factors, with smoking (76%) being the most recognized. The analyses indicated an association between family income and the number of prenatal consultations and between maternal education and the use of folic acid. There was no association between maternal education and the use of ferrous sulfate, nor between education and knowledge of risk factors. Conclusion: This study analyzed the socioeconomic profile of children with cleft lip and palate and their families, highlighting the importance of gestational planning, folic acid use, and knowledge about risk factors. The data reinforce the need for educational actions to improve prenatal care and reduce the incidence of cleft lip and palate through effective public policies. Editor: Universidade Federal da Paraíba Tipo: TCC

2024-10-30T00:00:00Z