https://repositorio.ufpb.br/jspui/handle/123456789/2334 2026-08-19T01:52:56Z 2026-08-19T01:52:56Z REGALADO, MATHEUS DE OLIVEIRA PEREIRA https://repositorio.ufpb.br/jspui/handle/123456789/38633 2026-08-08T06:10:35Z 2023-12-01T00:00:00Z

Título: EFEITO DOS CANABINOIDES NO TRATAMENTO DA FIBROMIALGIA Autor(es): REGALADO, MATHEUS DE OLIVEIRA PEREIRA Orientador: Araújo, Ricardo Henrique de Sousa Abstract: Fibromyalgia is a syndrome characterized by chronic pain associated with cognitive symptoms, fatigue, sleep disorders and psychiatric symptoms. The current prognosis is challenging, with limited treatment options and impaired quality of life. Considering the increased use of phytocannabinoids and their potential in the treatment of chronic pain, these substances may represent an important therapeutic approach for fibromyalgia. OBJECTIVES: to gather studies and analyze the available clinical evidence on the use of medicinal cannabis in the treatment of fibromyalgia. METHODOLOGY: A search was conduced out using the following descriptors: “fibromyalgia” AND “cannabis” on Biblioteca Virtual em Saúde do Ministério da Saúde (BVS MS) and PubMed in the last 10 years. RESULTS: From a total of 181 citations, 9 studies were included after screening the title, abstracts and full text. Of these studies, 2 were randomized controlled trials, 4 observational studies, and 3 systematic reviews. CONCLUSION: Although current evidence is limited, medicinal cannabis appears to be a safe alternative for the treatment of fibromyalgia. However, more studies on this topic are important so that there is strong evidence of its effectiveness in controlling pain in patients with fibromyalgia. Editor: Universidade Federal da Paraíba Tipo: TCC

2023-12-01T00:00:00Z LIMA JÚNIOR, ALYSSON JOSÉ SOUTO https://repositorio.ufpb.br/jspui/handle/123456789/38632 2026-08-08T06:10:37Z 2023-12-07T00:00:00Z

Título: EFEITOS DA PANDEMIA DE COVID-19 NO DIAGNÓSTICO DO CÂNCER DE MAMA EM HOSPITAL DE REFERÊNCIA DA PARAÍBA Autor(es): LIMA JÚNIOR, ALYSSON JOSÉ SOUTO Orientador: Porto, Lakymê Ângelo Mangueira Abstract: Breast cancer represents the most prevalent and lethal neoplasm in women today. It can be subclassified based on histology, immunohistochemistry, degree of differentiation, and carried oncogenes. Objective: The aim of the project is to assess the impact of the COVID-19 pandemic on the diagnosis of breast cancer in the state of Paraíba. Methodology: This is an observational cross-sectional study, quantitative, and predominantly descriptive, conducted through the collection of information regarding histological, sociodemographic, and clinical characteristics. Data collection was performed from medical records, gathering epidemiological and current tumor characteristics. Descriptive analysis of the obtained data was conducted by comparing multiple variables collected from breast cancer diagnosis at two time points: pandemic (2020 and 2021) and control (2019 and 2022) periods, as well as by comparing these variables using the Chi-Square and the Fisher’s exact test when feasible. Results: The data indicate a detriment in the initial staging of patients, as they presented proportionally more advanced stages during the pandemic period compared to the control period. Furthermore, there was a notable decrease in annual diagnoses at the institution in question that was not recovered in 2022. Conclusion: We conclude that between the pandemic and control periods, there was a predominance of more advanced early clinical stages during the pandemic, illustrating that the detriments of COVID translated into harm for breast cancer patients. Given that early diagnosis is crucial for optimal outcomes, this situation resonates both in the lives of patients and in the cost to the healthcare system, in the short and medium term, as interventions in advanced neoplasms are notably more costly compared to early-stage neoplasms. Editor: Universidade Federal da Paraíba Tipo: TCC

2023-12-07T00:00:00Z LEITE, ELTON DE SOUZA https://repositorio.ufpb.br/jspui/handle/123456789/38631 2026-08-08T06:10:38Z 2023-12-01T00:00:00Z

Título: ANÁLISE DO USO DA IBOGAÍNA NO TRATAMENTO DE TRANSTORNOS POR USO DE SUBSTÂNCIAS: UMA REVISÃO INTEGRATIVA Autor(es): LEITE, ELTON DE SOUZA Orientador: Araújo, Ricardo Henrique de Sousa Abstract: This work presents an analysis of the effectiveness of ibogaine in the treatment of substance use disorder, focusing on chemical dependency. Ibogaine is a hallucinogenic indole alkaloid and is the main active ingredient in the root of iboga, a species of shrub native to the African continent. Its potential in treating substance use disorders has gained increasing attention in recent decades, driven by preliminary studies suggesting its benefits in treating substance use disorder. OBJECTIVES: To review the evidence related to the use of ibogaine in the context of drug addiction, in relation to efficacy and related side effects and risks. METHODOLOGY: descriptive character, through an integrative literature review. Data were collected from databases (Pubmed, Virtual Health Library and Cochrane Library) using “substance-related disorders” descriptors; “ibogaine”; “therapy” searching for research published in the last 5 years that addressed evidence on the use of ibogaine in the treatment of chemical dependency in humans. Narrative reviews, abstracts and animal studies were excluded. RESULTS: 38 articles were found, of which 8 articles were analyzed. Quantitative and qualitative analysis revealed improvements in symptoms of depression, withdrawal and dependence severity, as well as positive impacts on individuals' social and legal conditions in the short and medium term. However, the temporal limitation of studies of up to 12 months makes it difficult to assess the durability of these benefits. Adverse events, such as cardiac arrhythmias, and deaths associated with the use of ibogaine have been described. Despite the promising results, the search for more solid evidence remains a priority. The need for specific clinical trials, consistent methodologies and further investigation are highlighted to support the use of ibogaine in the treatment of substance use disorders. Editor: Universidade Federal da Paraíba Tipo: TCC

2023-12-01T00:00:00Z LIMA, WENDERSON RENOVATO DE https://repositorio.ufpb.br/jspui/handle/123456789/35375 2025-07-31T06:08:14Z 2024-12-06T00:00:00Z

Título: Valeriana officinalis: PROPRIEDADES FARMACOLÓGICAS, APLICAÇÕES E SUAS INTERAÇÕES Autor(es): LIMA, WENDERSON RENOVATO DE Orientador: Santos, Roberto Mendes dos Abstract: The present thesis aims to investigate the pharmacological properties, applications, and interactions of the plant Valeriana officinalis, widely used in traditional medicine for the treatment of sleep-related disorders and anxiety. The research was structured into four main stages: choosing the guiding question, literature search, data collection and analysis, and discussion of the results. The central question formulated was: “What is the general overview of studies on Valeriana officinalis and its drug interactions?”. The literature review was conducted through the CAPES virtual library, using descriptors in Health Sciences. A total of 790 studies were identified, of which 14 were selected after reading titles and abstracts, resulting in 10 eligible articles and 3 additional from gray literature. The results indicate that most studies are reviews, with an emphasis on experimental investigations. The analysis of the collected data allowed for the identification of various therapeutic properties of Valeriana officinalis, as well as its interactions with other medications. This work contributes to the understanding of the therapeutic potential of the plant and its implications in clinical practice, highlighting the importance of further research to elucidate its properties and safety in use. Editor: Universidade Federal da Paraíba Tipo: TCC

2024-12-06T00:00:00Z