https://repositorio.ufpb.br/jspui/handle/123456789/2379 2026-09-21T12:11:55Z https://repositorio.ufpb.br/jspui/handle/123456789/39044 Título: Protocolos clínicos para farmacêuticos: guia para a tomada de decisão Autor(es): Ribeiro, Vinicius Soares Orientador: Reis, Walleri Christini Torelli Abstract: There is currently a significant demographic transition in society, with an exponential increase in life expectancy and, consequently, a higher prevalence of chronic diseases and continuous use of medications. This reflects an overload on health systems and a social demand for the inclusion of health professionals in the care process, with evidence-based clinical practice. Thus, the pharmacist, given their expertise in pharmacotherapy and their clinical skills, has the potential to improve outcomes and relieve health services. Therefore, the objective of the present work was the elaboration of clinical protocols for the management of chronic diseases by the pharmacist. For this, a literature review was carried out to identify the most prevalent diseases in primary care. After defining the diseases, an integrative review was carried out in two stages: investigation of the therapeutic protocols and guidelines in force in Brazil for the comorbidity in question and the search for recommendations for its management worldwide. All information collected was organized in a guide containing seven clinical protocols, divided into two axes: Cardiovascular and metabolic diseases (Hypertension, Diabetes Mellitus, Dyslipidemia, and Smoking Cessation) and Mental Disorders (Depression, Anxiety, and Bipolar Affective Disorder). Each protocol was organized into fourteen sessions. The preparation of this guide aims to guide the clinical practice of the pharmaceutical care clinic at UFPB and improve the quality of care provided therein, which can be expanded to other health services in the country and the world. Editor: Universidade Federal da Paraíba Tipo: TCC 2021-07-07T00:00:00Z https://repositorio.ufpb.br/jspui/handle/123456789/39043 Título: Cuidado interprofissional em saúde mental via teleatendimento em farmácia universitária frente à pandemia da COVID-19 Autor(es): Guia, Viviane Alvino da Orientador: Reis, Walleri Christini Torelli Abstract: As a result of the COVID-19 pandemic, many services underwent adaptations, as this study seeks to report the adaptation of an interprofessional mental health care center located in a university pharmacy in the face of the pandemic. To this end, a survey of data from the medical records of patients who already had links with the pharmaceutical care clinic was carried out, as well as new patients who were treated in the initial period of the COVID-19 pandemic (between April and June 2020) . The epidemiological profile, pharmacotherapeutic, methodology used for care and types of interventions were analyzed. N=81 patients, 67% female, prevalent age group 18 to 29 years. The most prevalent mental disorder among patients was Anxiety Disorder (76%), followed by Depressive Disorder (54%), Bipolar Affective Disorder (13%) and Panic Disorder (3%). Regarding the pharmacotherapeutic profile, the most prescribed drug class among the analyzed records was the Selective Serotonin Reuptake Inhibitors (SSRI) present in 54% of the records, with Sertraline being the most used in this class, corresponding to 62% of the SSRIs prescribed. As for the Selective Serotonin and Noradrenaline Reuptake Inhibitors (SNRI), Desvenlafaxine (82%) was the most prescribed drug. The use of Benzodiazepines anxiolytics was found to be reduced, appearing in only 12% of patients followed up during the period. As for the use of mood stabilizing drugs, Valproic Acid (46%) was the most commonly prescribed drug. With regard to the use of Antipsychotics, the most used was Quetiapine (90%), followed by Risperidone (7%) and Olanzapine (3%). About teleservices and telemonitoring, 93% were carried out by the case manager pharmacist and/or extension workers. Regarding interprofessional consultations, 68% related to the suggestion of medical prescription renewal. In this sense, the relevance of the interprofessional service in mental health becomes evident, as well as the role of the Pharmacist and his adaptation in times of health emergencies. Editor: Universidade Federal da Paraíba Tipo: TCC 2021-06-30T00:00:00Z https://repositorio.ufpb.br/jspui/handle/123456789/37327 Título: Isolamento e identificação de fungos dermatófitos em solo de áreas públicas no município de João Pessoa – Paraíba Autor(es): Souza, Annie Carollyne de Orientador: Rocha, Walicyranison Plínio da Silva Abstract: Dermatophytoses are skin infections caused by keratinophilic fungi that affect the stratum corneum of the skin and its appendages, leading to progressive inflammatory reactions. The main representatives of this group are distributed among the genera Trichophyton, Microsporum, and Epidermophyton. These are filamentous, septate, and hyaline fungi, capable of colonizing and causing clinical lesions in keratinized tissues. Species identification is essential for tracking and monitoring the predisposing factors of infection, as fungi causing dermatophytoses can be categorized into three groups based on their natural habitat: geophilic, zoophilic, or anthropophilic. The present study aimed to isolate and identify species of dermatophyte fungi from the soil of public squares and parks in the municipality of João Pessoa, Paraíba. Samples were collected using a previously sterilized spatula and sterile universal collectors. Sample processing involved inoculation on Sabouraud chloramphenicol agar and selective mycobiotic agar, in addition to the hair-bait method. A total of 30 soil samples were processed. No growth or isolation of dermatophytes was observed on the culture media used. However, growth was noted using the hair-bait method (13 samples; 43.3%). Trichophyton rubrum was the only species isolated (13 samples; 100%). The hair-bait technique is the optimal method for isolating keratinolytic fungi from soil samples. T. rubrum is the most prevalent species found in the soil of the collected urban areas. Conducting research with environmental samples allows us to contribute to epidemiological studies and facilitates the adoption of effective strategies for raising awareness, preventing and controlling the population, promoting better use of these spaces. Editor: Universidade Federal da Paraíba Tipo: TCC 2024-10-30T00:00:00Z https://repositorio.ufpb.br/jspui/handle/123456789/37326 Título: Alérgenos e suas respostas fisiopatológicas em modelos murinos de indução da asma: uma revisão integrativa Autor(es): Cavalcanti, Alexya Mikelle Teixeira Orientador: Oliveira, Fabiana de Andrade Cavalcante Abstract: Asthma is a chronic inflammatory disease that affects approximately 29% of the global population and is a significant public health issue. Its complex pathogenesis, characterized by bronchial hyper-responsiveness, inflammation, and airway remodeling, makes animal models essential tools for studying this disorder. Through these models, it is possible to investigate the underlying mechanisms of asthma, from sensitization to allergens to the development of new therapies. Various murine models replicate different aspects of human asthma, each with its own advantages and limitations. To induce asthma in mice, various allergens are used, including ovalbumin, lipopolysaccharides, house dust mites, particulate matter, and cockroach allergens. The choice of the appropriate model depends on the specific research objectives, such as the phenotype and pathophysiology of asthma to be studied and the desired immune response. This work aims to conduct an integrative literature review on the types of allergens used in different murine models for asthma induction and analyze the pathophysiological mechanisms underlying allergic asthma. An integrative literature review was performed in the databases PubMed, Science Direct, and Scopus over the last 10 years using descriptors such as "smooth muscle," "rat," "mouse," "guinea pig," "asthma," "animal model," "allergens," and "asthma model" in English. It was observed that between 2014 and 2024, 1,728 articles were published; according to inclusion and exclusion criteria, 157 of these studies addressed the murine asthma model, considering aspects of pathophysiology, applicability, and results in these experimental models. Like human asthma, murine models of asthma induction show increased infiltration of eosinophils, neutrophils, leukocytes, macrophages, and monocytes, as well as inflammatory mediators such as various interleukins, IgE, TNF- α, and IFN-γ. Additionally, there is hypertrophy and hyperplasia of epithelial cells and goblet cells in the smooth muscle of the airways—factors responsible for hyperresponsiveness and changes in pulmonary function. Therefore, it is concluded that using allergens in mice is an essential tool for understanding the immunological mechanisms involved in asthma, allowing for the simulation of aspects of allergic asthma. This evaluation enables testing the efficacy of new substances with therapeutic potential for treating this disorder while considering the heterogeneity of the disease and its multiple exacerbating factors. Editor: Universidade Federal da Paraíba Tipo: TCC 2024-11-06T00:00:00Z