https://repositorio.ufpb.br/jspui/handle/123456789/2374 Wed, 16 Sep 2026 09:25:16 GMT 2026-09-16T09:25:16Z https://repositorio.ufpb.br/jspui/handle/123456789/39038 Título: Polimorfismos do antígeno leucocitário humano (HLA) e sua ligação com a infertilidade Autor(es): Souza, Maria Bárbara Moreira de Orientador: Assis, Priscilla Anne Castro de Abstract: Infertility affects approximately one in six people of reproductive age globally, and about 15% of cases remain without an identified cause after standard investigation, being classified as unexplained infertility. Emerging evidence points to the immune system as a critical factor in these cases, particularly concerning maternal-fetal tolerance mediated by the Human Leukocyte Antigen (HLA) system. The present study consists of an integrative literature review aimed at investigating the association between HLA gene polymorphisms and adverse reproductive outcomes. The search was conducted in the PubMed and Academic Search Premier databases, covering publications between 2020 and 2025, resulting in the selection of 21 original studies and meta-analyses. The findings were organized into summary tables and critically analyzed. Regarding HLA-G, evidence demonstrated that the 14-bp INS/DEL polymorphism is associated with recurrent pregnancy loss (RPL), with effects dependent on haplotypic context and ethnicity. HLA-F emerged as a novel player in implantation, with endometrial expression modulated by SNPs rs1362126, rs2523405, and rs2523393, and correlated with regulatory T cells. HLA-E showed a significant association with male infertility (HLA-E*01:01 genotype) but not with female outcomes. The HLA-C/KIR/ERAP axis revealed complex interactions: the KIR Tel AA + HLA-C2C2 combination conferred risk for recurrent implantation failure (RIF), a risk modulated by polymorphisms in ERAP1 (rs26653, rs26618, rs27044, rs30187), with serum ERAP2 levels emerging as a potential prognostic biomarker. HLA class II genes (DRB1, DQB1, DQA1, DPB1) showed markedly population-specific associations, notably the sharing of one HLA-DQB1 allele between spouses in 46% of couples with RPL in the Chinese population. The marked population heterogeneity observed reinforces the need for studies in diverse ethnic groups and caution in generalizing findings. It is concluded that polymorphisms of the HLA system and correlated genes constitute central elements in the etiology of immune-mediated infertility, acting in complex interaction networks involving haplotypes, epistasis, and parental genotypic combinations. Editor: Universidade Federal da Paraíba Tipo: TCC Tue, 31 Mar 2026 00:00:00 GMT https://repositorio.ufpb.br/jspui/handle/123456789/39038 2026-03-31T00:00:00Z https://repositorio.ufpb.br/jspui/handle/123456789/38162 Título: Mecanismos de regulação cardiometabólica induzidos pelo exercício físico na prevenção da aterosclerose: uma análise in silico Autor(es): Silva, Daniele Diniz da Orientador: Martin, Christina Pacheco Santos Abstract: Atherosclerosis is a chronic, multifactorial inflammatory pathology and a leading cause of global mortality, necessitating the investigation of robust preventive strategies. This study aimed to investigate, through bioinformatics and systems biology approaches, the molecular mechanisms by which physical exercise modulates cardiometabolic pathways and prevents disease progression. The methodology consisted of quantitative and descriptive in silico research, based on cross-referencing transcriptomic data from the Fitnoma catalog with the atherosclerosis pathway from the KEGG database, followed by the construction of Protein-Protein Interaction (PPI) networks via the STRING platform and functional enrichment analysis using WebGestalt. The results identified 42 common genes, revealing a molecular network with remarkably high connectivity. The PLCG1 gene emerged as the primary hub involved in calcium signaling and eNOS enzyme activation—processes essential for maintaining vascular homeostasis. Furthermore, critical axes for cell survival (PI3K-AKT) and inflammatory modulation (TLR4-MAPK) were identified. Enrichment analysis highlighted immune system regulation as the central biological process mediated by exercise. In conclusion, physical activity exerts a systemic cardioprotective impact by acting as a coordinated biological cluster that mitigates systemic inflammation, reverses cellular damage, and stabilizes atherosclerotic plaques through gene transcription modulation. These findings validate the use of computational tools for discovering therapeutic Editor: Universidade Federal da Paraíba Tipo: TCC Fri, 27 Mar 2026 00:00:00 GMT https://repositorio.ufpb.br/jspui/handle/123456789/38162 2026-03-27T00:00:00Z https://repositorio.ufpb.br/jspui/handle/123456789/38161 Título: Análise in-silico da regulação gênica pelo exercício físico sobre as vias moleculares ligadas à doença de Parkinson Autor(es): Silva, Gabryella Hellen Maracajá Coutinho da Orientador: Martin, Christina Pacheco Santos Martin Abstract: Physical exercise has been an important non-pharmacological treatment for chronic non-communicable diseases, such as Parkinson's Disease, a progressive neurodegenerative disease that primarily affects the central nervous system and whose incidence is increasing. Therefore, the objective of this work is to analyze gene regulation of molecular pathways linked to Parkinson's Disease through physical exercise, aiming to provide evidence supporting the practice of exercise as a non-pharmacological treatment and to generate subsidies for the development of biomarkers. The methodology employed was based on the FITNOME Catalog and through an analysis of bioinformatics platforms such as SportsXbiodata, WebGestalt, KEGG, STRING, miRWalk, and Cytoscape for filtering and integration, enrichment, mapping, protein interactions, microRNA interactions, and network visualizations of the interactions. Thus, the results of this work demonstrate the regulation of all genes associated with this disease through physical exercise, indicating an adaptive modulation of these genes induced by physical exercise. This modulation results in the regulation of biological processes mainly related to mitochondrial autophagy, in addition to promoting metabolic and molecular adjustments in cells. Interactions between proteins were shown to be highly branched, revealing a large cascade effect. Furthermore, interactions between microRNAs and genes highlighted central hubs as potential therapeutic targets and biomarkers. Finally, in conclusion, physical exercise appears to be a promising non-pharmacological treatment for Parkinson's Disease, as shown by all the analysis performed; physical exercise acts as an adaptive regulator of Parkinson's genes. Thus, this work clarifies and opens new avenues for research on the regulation of Parkinson's Disease through physical exercise, indicating a relevant mechanism with possible overall metabolic improvement of the genes and proteins involved in the regulatory processes of this disease. Editor: Universidade Federal da Paraíba Tipo: TCC Mon, 30 Mar 2026 00:00:00 GMT https://repositorio.ufpb.br/jspui/handle/123456789/38161 2026-03-30T00:00:00Z https://repositorio.ufpb.br/jspui/handle/123456789/38157 Título: Terapia CAR-T: avanços e perspectivas no Brasil Autor(es): Souza, Maria Beatriz Nascimento Marinho de Orientador: Dejani, Naiara Naiana Abstract: CAR-T cell therapy (Chimeric Antigen Receptor T-cell therapy) represents one of the most advanced immunotherapy strategies in the treatment of hematological malignancies. This study aimed to list the drugs approved by ANVISA (Brazilian Health Regulatory Agency) for CAR-T therapy in Brazil, discuss their main therapeutic targets, analyze the progress and future prospects of the therapy in the country, identify its main obstacles, and clarify the eligibility criteria for patients and access to treatment. This is an integrative narrative review, conducted in the PubMed, SciELO Brazil, LILACS, and CAPES Periodicals databases, supplemented by institutional documents, regulatory reports, and official clinical trial records. The systematic search did not identify original articles with complete clinical results published in Brazil, due to the fact that the first national clinical trial, the CARTHEDRALL Study (NCT06101381), is still ongoing. The materials found include reviews, institutional communications, and technical updates from organizations such as ANVISA, INCA, Instituto Butantan, Fundação Hemocentro de Ribeirão Preto, and FIOCRUZ. The results indicate that Brazil is advancing in the production and clinical application of the therapy, with national experimental platforms and a growing laboratory infrastructure. However, challenges persist, such as the absence of fully consolidated regulatory frameworks, high costs, production complexity, and limited patient access. It is concluded that the country possesses increasing scientific and technological capacity to consolidate CAR-T therapy, provided there is a strengthening of public policies, expansion of research, and integration between health centers, universities, and regulatory bodies, enabling this innovative technology to become accessible and sustainable within the Unified Health System (SUS). Editor: Universidade Federal da Paraíba Tipo: TCC Wed, 01 Apr 2026 00:00:00 GMT https://repositorio.ufpb.br/jspui/handle/123456789/38157 2026-04-01T00:00:00Z