Perfil de sensibilidade antifúngica das cepas do complexo sporothrix schenckii coletadas em um hospital universitário em João Pessoa – PB

Abstract

Sporotrichosis is a subcutaneous mycosis, responsible for fungi belonging to the Sporothrix schenckii complex, which affects both human and animals. Studies on the antifungal sensitivity profile of species belonging to this group are still scarce, although the number of cases of sporotrichosis increased exponentially each year. It is important to know the most prevalent species in each region, and submit them to antifungal sensitivity tests for an effective treatment through the use of appropriate antifungal agents. Thus, this study caims to evaluate the profile of sensitivity to the antifungal agents amphotericin B, voriconazole, fluconazole and itraconazole, from 24 strains of the Sporothrix complex, from a phenotypic characterization study by FERREIRA, JS, whose strains were collected from patients attended at a University Hospital, in the city of João Pessoa - PB. The antifungal activity of the tested drugs was evaluated by the microdilution method, according to procedures reported in CLSI M38. In general, voriconazole was more active followed by amphotericin B, whereas itraconazole showed less activity and fluconazole was not active in any of the strains tested. Three isolates showed resistance to itraconazole, one S. schenckii and two S. brasiliensis. Two isolates showed resistance to both itraconazole and amphotericin B, one isolate S. schenckii and one S. brasiliensis. This study found differences in antifungal sensitivity between the S. brasiliensis and S. schenckii species.