Detomidina intranasal em equinos: Efeitos sistêmicos da dose de 20 mcg/kg

Abstract

The objective of this study was to evaluate the degree of sedation and systemic effects of intranasal detomidine at a dose of 20 mcg/kg in six clinically healthy horses. The head height (HH), visual stimulus response (VSR), sound stimulus response (SSR), respiratory rate (RR), heart rate (HR), systolic blood pressure (SBP), rectal temperature (RT), blood glucose, hematocrit, intraocular pressure (IOP) and intestinal motility were measured at baseline (M0) and at five different times (M15, M30, M45, M60 and M75) 15 minutes with an interval between them. Statistical difference (p ≤ 0.05) is obtained only in the assessment of intestinal motility of the right ventral colon at M30 and M45 (3.5 [3-4] mpm) and left ventral colon at M45 (3.5 [3 -4] mpm) relative to M0. The results of HH, VSR and SSR evaluation showed a higher degree of sedation in M45. At this same time, RR (6.5 [5-11] mpm), hematocrit (27.5 [24-41] %) and IOP LE (39 [12-43] mmHg) differed from the physiological parameters of the species. It concluded that a 20 mcg / kg intranasal detomidine promotes mild sedation in horses for approximately 45 minutes, no significant changes in the clinical parameters, and is not recommended for long and invasive procedures.