Instabilidade do intervalo QT em cães doentes renais crônicos.

Abstract

Chronic kidney disease is a pathology that leads to a decrease in the glomerular filtration rate and that most commonly affects geriatric dogs and can also affect young animals. The effective functioning of the heart, in turn, is closely related to blood electrolytes. Cardiorenal syndrome (CRS) is a pathological condition that relates the kidney and the heart as the first affected organ, be it the heart or kidney, can perpetuate direct and indirect effects on the second organ, characterizing a mutual dysfunction. Thus, due to the close relationship between these organs and cardiovascular changes being one of the causes of death in renal patients, the present study aimed to identify possible changes in the QT interval of chronic kidney sick dogs and to correlate them with biochemical findings. A total of 19 dogs, between males and females, of varying ages, with or without defined breed, were used and were allocated into two groups: Control Group (C), of healthy animals, and Group of Chronic Kidney Patients (CKD). Total instability (IT) was greater in the CKD group compared to the C group. The serum concentrations of creatine and urea in the CKD group proved to be higher than those in the C group, as well as the concentrations of PO4-, K+, and Ca++. The correlations between creatinine concentrations vs QTm, PO4- vs QTv and PO4- vs CIT, were positive in the CKD group. Negative correlations were found between the concentrations of Na+ vs LIT, in addition to the concentration of K+ vs LIT in the CKD group. In group C, there was no significant correlation between biochemical variables and QT interval instability indices. Finally, it can be concluded that the instability of the QT interval is present in dogs with chronic kidney disease, which are strong candidates for developing ventricular arrhythmias and that these arrhythmias are related to electrolyte changes involving PO4-, Na+, K+.