Híbridos moleculares derivados do álcool perílico e borneol : avaliação antifúngica

Abstract

The genus Candida is responsible for the majority of fungal infections in hospital settings. Currently, several researches are directed to search for new bioactive products in the face of species of this genus. Literature data relate molecules with a perillyl or borneol nucleus that have antimicrobial activity. In previous studies, carried out by our research group, it has been demonstrated that the use of chemical and benzoic substances conjugated to monoterpenes is an interesting strategy to obtain new anti-Candida prototypes. Therefore, allow the search for candidates for antifungal drugs, in this case, the investigated dissertation or antifungal potential of eleven molecular hybrids composed of perillyl alcohol and alcohol derivatives as substructures chemical or chemical substances. Use three methods in the esterification analysis: Preparation of acid chloride via SOCl2, Steglich esterification and Schotten-Baumann reaction; the benefits of the products vary between 22.5% and 40.4%. Of the eleven selected hybrids, eight are synthetic derivatives of credits in the literature. No forward antifungal tests such as the species C. albicans, C. krusei and C. tropicalis, determined a MIC (minimal inhibition) with a microdilution technique in the 96-well plate and a minimal fungicide (CFM) in the culture medium. In the evaluation of the antifungal capacity of the hybrids, it was possible to observe all bioactives in front of the tested strains, exhibiting fungicidal activity. The compounds with the greatest antifungal power were bioactive against the strain of C. albicans, which, MF3 shows MIC at a concentration of 186.88 μM and MF5 at 622.50 μM, followed by compound MF10 which shows MIC at a concentration of 1659.27 μM against a strain of C. tropical, all compounds tested against C. krusei showed activity at the highest concentration tested. The data suggested for the presence of bulky lipophilic groups as substituents in the aromatic ring potentiate the antifungal action of molecular hybrids.