Prospecção tecnológica de diterpenos do tipo labdano e seus derivados como agentes anticâncer

Abstract

In the modern world, studies related to the production of drugs have been closely related to the investigation of medicinal plants due to the various substances of pharmacological interest found in them, such as, for example, terpenoids, which are one of the most widespread classes of natural products. Terpenoids are made up of different subclasses such as, for example, monoterpenes, diterpenes, triterpenes and tetraterpenes. Diterpenes are a class of terpenes with twenty carbon atoms that have different arrangements of hydrocarbon skeletons. Among the various classes of existing diterpenes, the present work has only investigated the technological potential of labdanes diterpenes and their derivatives as anticancer agents based on a survey of patent filings in the period from 2010 to 2020. Technological prospecting was performed at the bases (INPI, EPO and WIPO). In these technological information bases, the results show few patents related to the subject under analysis, including in the Brazilian database, no results were listed in the research for the investigated period. The low rate of patent filings related to the technological / pharmacological use of labdane-type diterpenes and their derivatives to anticancer therapies is quite contrasting with the volume of scientific information related to the topic, which may suggest that there is still a field to be explored in the conversion of scientific knowledge into technological knowledge for this class of substances.