Análise dos efeitos de um programa de redução de estresse baseado em mindfulness sobre correlatos cerebrais e posturais em pacientes com migrânea

Abstract

Migraine is a pathology whose symptoms directly affect the individual's personal and work life, jeopardizing the daily chores and social relationships momentarily. Considered difficult to diagnose, its pathophysiology is still imprecise, however, despite the several hypotheses to explain the genesis of the referred disease, the most accepted one considers that migraine consists of a dysfunction in the excitability of cortical neurons, which, in turn, promotes a wave of occipital-frontal depolarization, followed by a period of suppression of neuronal activity. Parallel to the studies that seek to explain the pathophysiological aspects of chronic migraine, another current of research presses to observe and understand how the neuronal activity of these patients is characterized, in order to support the construction of future therapeutic proposals. For this purpose, in the construction of this dissertation, the theoretical framework of the variables to be analyzed in the study (electroencephalographic records of alpha asymmetry, head movement patterns and emotional states) was initially carried out, laid down in the first chapter of the work, and then an observational cross-sectional study of brain and postural correlates was performed in patients with migraine who participated in a stress reduction program based on mindfulness. The objective was to evaluate the relationship between the clinical perception of pain in patients with migraine, as well as to establish possible neurophysiological signatures related to the pathological process, through electroencephalographic and head movement findings. Significant correlations were found

between alpha wave power in the right and left frontal hemispheres, head movement and self- reports of the severity of migraine symptoms and the state of mindfulness in the participants.

These preliminary results indicate that the frontal alpha power and head movements could function as biomarkers of migraine and mindfulness.