Desenvolvimento magistral de chocolate mendicamentoso isento de sacarose e lactose

Abstract

It is known that most drugs available on the market do not have attractive features for children, as they have organoleptic characteristics, such as: unpleasant taste, odor, shape and texture. In addition, there is a shortage of drugs with dosage, dosage and pharmaceutical form suitable for pediatrics. These factors hinder medication adherence by children, triggering the need to implement strategies that can overcome these obstacles. Therefore, it is increasingly necessary to incorporate active principles in attractive pharmaceutical forms that have pleasant palatability. An example of this is chocolate, a soft tablet capable of masking the characteristic flavor of pharmaceuticals. Sucrose and lactose are commonly used to make the medicine taste more pleasant, however, the use of the first contributes to the development of tooth decay and restricts consumption by diabetic patients; the second limits its use by intolerant patients. With this audience in mind, and since Ibuprofen is a drug frequently used in pediatrics, this study aimed at the masterful development of medicated chocolate free of sucrose and lactose, as well as the determination of product quality parameters, such as: pH; average weight; friability; toughness; disintegration and organoleptic characteristics. The formulation preparation resulted in the drug taste masking, presenting pleasant odor, palatability, shape and texture. The final product had a mean coefficient of variation of 3.8%; average weight 8.032 g; average pH of 5.8 and average hardness of 6.67 Kgf. Furthermore, the friability tests showed a loss of 0.77% and disintegration occurred within 2 minutes and 6 seconds, within the recommended limits. Thus, the elaborated formulation showed stability and adequate physical, chemical and organoleptic characteristics.