PREVALÊNCIA DE SUPERCRESCIMENTO BACTERIANO DO INTESTINO DELGADO EM PACIENTES COM DOENÇA HEPÁTICA GORDUROSA NÃO ALCOÓLICA EM HOSPITAL UNIVERSITÁRIO NA CIDADE DE JOÃO PESSOA - PB

Abstract

Non-alcoholic fatty liver disease (NAFLD) is related to the presence of fatty liver when there is no secondary cause, such as alcohol, for the accumulation of fat in the liver. Small intestinal bacterial overgrowth (SIBO) is characterized by a bacterial count greater than or equal to 105 CFU / ml in the proximal small intestine. Since 1970, data has suggested that SIBO could play a role in NAFLD. In Brazil, data on the prevalence of SIBO in patients with NAFLD and the correlation with the degree of liver fibrosis in this population are scarce and need further studies. In this sense, knowing the high prevalence of NAFLD in the population, one realizes the importance of further research on the topic. The study aims to assess the prevalence of SIBO in patients with NAFLD treated at a university hospital in the city of João Pessoa - PB. This is a cross-sectional, quantitative epidemiological study, based on the expired hydrogen test, for measuring the SIBO. In addition, an anthropometric and laboratory evaluation was

carried out, classification of patients at risk for advanced fibrosis according to the NFS (Non- alcoholic fatty liver disease fibrosis score) score. The study involved 48 patients with

NAFLD, between 18 and 75 years old, seen at the Gastroenterology and Hepatology service of Hospital Universitário Lauro Wanderley, in João Pessoa - PB, from April to December 2019 and who signed the IC. Of the 48 patients evaluated, 54.17% were female and 45.83% were male; 72.9% had diabetes mellitus and 54.17% had obesity (BMI> 30). Of the total number of individuals, only 4 were positive for SIBO, with a total prevalence of 8.33% of the sample. Therefore, the prevalence of SIBO in our study was notably lower than the current studies of prevalence in other countries, which bring values ranging from 31.3% to 60%. Evaluating among the risk groups for advanced fibrosis, the prevalence of SIBO was similar between the groups. Thus, further studies are necessary that demonstrate a statistically significant difference between the groups.