Comparação entre modelos experimentais de interação química de polivinilpirrolidona e quitosana

Abstract

The development of dressings based on renewable sources is gaining more and more space in the medical and biomedical field, as in addition to being a biodegradable alternative, it is a specific and effective process for the treatment or repair of organs, tissues and functions of the human body. . Due to their physical-chemical, mechanical and biological properties, dressings based on renewable sources are a promising alternative for several applications, such as, for example, those caused by radiation. Thus, polyvinylpyrrolidone and chitosan biopolymers have biological and physical-chemical properties, with great conversion in the treatment of skin wounds, which can be individualized. Therefore, analyzing the chemical interaction behavior between these polymeric biomaterials is necessary to improve and/or acquire new properties. The objective of this work was to evaluate the quiet chemistry of PVP/Chitosan mixtures, through modeling using a linear model and compare with experimental data obtained, using experimental optimization by the response surface methodology using the Box-Behnken model, from Fourier transform infrared spectroscopy (FTIR) results. We conclude that qualitatively the models show a reduction in the interaction area with the increase in the proportion of chitosan, favoring hydrogen bonds, and that the experimental model presents a better statistical adjustment to characterize the miscibility of the blends from the proposed mathematical model.