Dexmedetomidina e Midazolam intranasal em galinhas domésticas (Gallus gallus domesticus): efeitos clínicos e histopatológicos

Abstract

In order to evaluate the clinical and histopathological effects of dexmedetomidine and midazolam, associated (MDEX - midazolam 0.5 mg/kg + dexmedetomidine 40 µ/kg) or not (DEX - dexmedetomidine 80 µ/kg and MID - midazolam 1 mg/kg), 36 healthy domestic chickens received these drugs intranasally and underwent clinical evaluation of the following parameters: respiratory (f) and heart (HR) rates, media blood pressure media, cloacal temperature and sedative rate. Clinical evaluation was carried out before administration of drugs, after five minutes (M5) and every 15 minutes until completing 65 minutes (M65); after this time, evaluation was performed every 30 minutes until sedation recovery. Following a draw, birds were euthanized 24 or 168 hours after administration of drugs and histopathological changes in the nasal epithelium were evaluated. Results obtained were subjected to statistical tests for asymmetric data. It was noted in the DEX group, in the M5, tachypnea in relation to the other groups and HR higher than the MID group. It is possible to observe a reduction in HR in all groups and moments, but within the reference values, and maintenance of blood pressure. The cloacal temperature decreased over time in the DEX and MDEX groups. The animals in the MID group did not present sedation. In the MDEX group, adequate sedation and minimal cardiovascular effects were observed. Epithelial lesions were observed in all groups and varied from mild to severe after 24 hours and absent to mild after 168 hours of administration. These histopathological lesions need to be further investigated.