Detecção do papilomavírus humano 16 e 31 em carcinoma mamário de pacientes do estado da Paraíba

Abstract

Several studies have detected Human Papillomavirus (HPV), particularly HPV16, in breast tumors. It is known that the Northeast Region of Brazil has a high prevalence of HPV16 and 31 in cervical neoplasia and cervical cancer. However, there are few studies of the detection of HPV16 and 31 in breast cancer (BC) in the population of Northeast Brazil, and there is no study in the State of Paraíba. Thus, the objective of this study was to detect HPV16 and 31 in MC of women in the State of Paraíba, Northeastern Brazil. One hundred eighty-six paraffin blocks containing breast carcinoma fragments were analyzed, including Luminal A, Luminal B, HER2, Super HER2, and Triple negative. Viral DNA detection was performed by conventional PCR and q-PCR. HPV DNA was detected in 48,38% (90/186) breast cancer specimens. HPV16 was detected in 44% (83/186) of cases. HPV31 was detected in 3.5% (7/189) of patients. HPV16 and 31 coinfection was found in 1.6% (3/186). A significant association was observedbetween HPV-positive CM samples, Ki-67>30 (p>0.05), and mitotic index (p>0.05). Thus, thehigh prevalence of HPV as well as the possible role in the aggressiveness of BC should be better understood in regions with a high prevalence of HPV.