Desenvolvimento de derivados tetrahidroisoquinolínicos e construção de aparelho de eletrólise de baixo custo

Abstract

The development of synthetic methodologies is a highly studied area by organic chemists, as finding new routes is ideal for improving reaction costs and yields. These improvements can also be related to the production of tools to serve as a source of some reagent or procedure. Thus, the objective of this work is to synthesize bisphenyltetrahydroisoquinoline derivatives and evaluate their antimicrobial activity in bacterial and fungal strains, in addition to describing the production of a low-cost electrolysis apparatus. The research methodology involved a multifaceted approach, starting with the bromination of vanillin, followed by the Ullmann reaction to form the diphenyl ether. The research progressed with the synthesis of bisphenyltetrahydroisoquinoline and demethylated derivatives, using advanced purification techniques and characterization by nuclear magnetic resonance spectroscopy. In addition, significant antimicrobial tests were conducted on various bacterial and fungal strains, highlighting the efficacy of the MHTP and DiMHTP compounds. Concurrently, the study included the construction of a compact electrolysis apparatus, crucial for the production of hydrogen gas used in the hydrogenation of acrylamides, a vital step in modifying chemical properties and in the synthesis of bioactive compounds with potential pharmacological applications. Three main areas were explored: the synthesis of isoquinoline derivatives, antimicrobial assays, and the application of a compact electrolysis apparatus. In the synthesis, using techniques such as the Pictet-Spengler reaction, bistetrahydroisoquinoline derivatives were developed with structures confirmed by nuclear magnetic resonance spectroscopy. In the antimicrobial assays, the MHTP and DiMHTP compounds demonstrated differentiated activity, with MHTP showing greater efficacy against fungal strains, highlighting the potential of isoquinolines as antimicrobial agents. Finally, the compact electrolysis apparatus proved crucial in the production of hydrogen gas for the hydrogenation of acrylamides, opening new possibilities for the synthesis of bioactive compounds with improved pharmacological properties. This research represents a significant advancement in pharmacochemistry, offering new perspectives for the development of more effective drugs and treatments.