Desenvolvimento e avaliação de enxaguatórios com associação de extrato de gengibre (Zingiber officinale Roscoe) e fluoreto de sódio : estudos in vitro

Abstract

Few products have combined essential oils and sodium fluoride to develop herbal mouthwashes with the aim of simultaneously reducing biofilm and promoting remineralization. This combination is particularly important for patients with rapid progression and white spot lesions, such as those wearing orthodontic appliances. The objective of this study is to evaluate in vitro the physicochemical stability of ginger extract (Zingiber officinale Roscoe) in association with sodium fluoride (0.05% NaF), with the potential to prevent/control the development of white spot lesions caused by caries.For this purpose, solutions were prepared containing traditional Rabelo® water, ginger, and Zingiber officinale extract (ginger), labeled as G1, G2, and G3, respectively. Each solution was adjusted to contain 225 ppm of fluoride (F-), using 5% diluents (Tween 80 and DMSO) to enhance solubility and stability. pH and fluoride concentration analyses were performed through potentiometry, using standard solutions of 0.5 to 10 ppm of F- and TISAB II. The samples were stored for 11 weeks at room temperature, 37°C, and 45°C, simulating accelerated aging.The results showed a reduction in sodium fluoride concentration for all groups over the weeks, with G2 showing the highest mean value (168.44 ppm F- and SD=76.02) at 37°C, remaining within the normal range (175 ppm < [F-] < 275 ppm) for 4 weeks, and CP1 showing the lowest mean value (123.58 ppm F- and SD=45.85), remaining outside the range for all weeks at both 25°C and 37°C. The pH of all samples varied at different temperatures over time, with an acidic tendency predominantly for G3 (3.78) at 37°C and 3.83 at 45°C.Thus, we can conclude that regardless of the temperature, the substances lose sodium fluoride over time due to the presence of compounds that chemically interact with F-, which need to be identified and eliminated for better stabilization of the compounds in association with fluoride. Additionally, excessive acidity may pose a risk of dental erosion.