Potencial anti-inflamatório da musa paradisiaca associado à modulação do estresse oxidativo em modelos experimentais: uma revisão da literatura

Abstract

The maintenance of organismal homeostasis depends on a balance between pro-inflammatory and antioxidant mechanisms. Disruption of this balance, often characterized by increased inflammatory mediators and excessive production of reactive species, contributes to the progression of various chronic diseases. In this context, plant-derived bioactive compounds have been widely investigated due to their therapeutic potential. Musa paradisiaca , commonly used in both diet and traditional medicine, stands out for its richness in secondary metabolites with antioxidant and anti-inflammatory properties. This study aimed to critically analyze the scientific evidence regarding the anti-inflammatory and antioxidant potential of Musa paradisiaca in experimental models. This is a qualitative narrative literature review, including recent studies addressing the biological activity of the species, its bioactive compounds, and underlying mechanisms of action. The findings indicate that different plant extracts are capable of modulating the inflammatory response by inhibiting pro-inflammatory mediators, such as cytokines (TNF-α, IL-1β, and IL-6), as well as regulating signaling pathways, particularly NF-κB, and reducing the activity of enzymes such as phospholipase A₂. In addition, significant antioxidant activity was observed, mainly attributed to phenolic compounds and flavonoids, which can neutralize reactive oxygen species and contribute to the attenuation of inflammation. It can be concluded that Musa paradisiaca presents promising potential as a source of bioactive compounds with therapeutic applications. However, further studies, especially clinical trials, are needed to better elucidate its mechanisms of action and to validate its efficacy in humans.