Efeitos do consumo materno de dieta hiperlipídica pré-concepcional e gestacional sobre perfil de ácidos graxos e morfologia do eixo entero-hepático da prole de ratos wistar

Abstract

Maternal consumption of high-fat diets, especially during critical periods such as preconception and pregnancy, can significantly affect offspring metabolism and health. This experimental study evaluated the effects of a maternal high-fat diet on the fatty acid profile and morphology of the enterohepatic axis in Wistar rat offspring. Four Wistar rats were fed a high-fat diet (31.8% lipids; 4.34 kcal/g) for 55 days prior to conception and throughout pregnancy. Litters were standardized to eight pups per mother (four males and four females), and at weaning (21 days), liver and intestinal samples were collected for fatty acid profile analysis and histological evaluation. Hepatic and intestinal lipid profiles, as well as liver and intestinal histology, were analyzed in males and females after weaning.