Membranas à base de quitosana, poli(álcool vinílico) e casca de banana madura visando aplicação como curativo cutâneo

Abstract

The use of biomaterials for application as cutaneous dressings has recent years, since the treatment of cutaneous a worldwide problem due to the numerous complications that can occur during the process of healing. Therefore, the use of membranes composed of chitosan (CS) and poly (vinyl alcohol) (PVA) appears as a promising alternative for obtaining biomaterials for potential use as curatives. In addition to these advantages, the The banana peel powder (PCB) has also been used in this study, due to its healing power, due to the presence of secondary metabolic tannins, as well as significant antimicrobial activity against bacteria, fungi and yeasts. The pure CS and PVA membranes; CS, PVA and CS / PVA (1: 4) with 10% PCB mass; as well as the CS / PVA membrane (1: 4) with 10% by mass of PCB and 3% by mass of AN were prepared by the solvent evaporation method (casting). THE structure, morphology and physical properties of the membranes were evaluated. On one In general, the membranes presented flexibility, malleability and adhesiveness when analyzed macroscopically. The mean values ​​of membrane thickness were compatible with the thicknesses of dressings already reported in the literature. The X-ray diffractograms of the membranes containing 10% by weight of the shell banana suggested a relative influence of this charge on the membrane structure, in order to interfere with the crystallinity of the different compositions. The CS + 10% PCB membrane showed a higher degree of swelling after 48h in distilled water solution (pH = 5.5). SEM micrographs revealed that the presence of clay in the CS / PVA composition (1: 4) + 10% PCB + 3% AN promoted good dispersion and distribution of PCBs in the matrix CS / PVA, possibly showing a good interaction between both components PCB / AN. Thus, the membranes studied in this research presented properties to be used as dressings, CS + 10% PCB membrane which presented compatible characteristics for such application.