Preparo e caracterização de esponjas à base de quitosana e policaprolactona (PCL)

Abstract

Considering the great advance in the area of ​​biomaterials, more specifically in engineering together with the possible antimicrobial and anti-inflammatory action of chitosan, in the present work, sponges based on chitosan and polymer blends of chitosan / polycaprolactone (PCL) were synthesized and characterized, with the objective of analyzing its bioactivity in biological assays, aiming application in the treatment of oral infections. O preparation of the chitosan and PCL solutions were done separately, with subsequent mixing of the solutions in different volume / volume (v / v) ratios of chitosan and PCL: 100% chitosan (pure chitosan), 75% chitosan and 25% PCL (75/25); 50% chitosan and 50% PCL (50/50), for then application of the freeze-drying technique resulting in the formation of the structure spongy To characterize the samples, the visual aspect, the Calorimeter Differential Scanning (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and the Zeta Potential. The sponges formed only by pure chitosan presented a higher density and flexibility than blends. Essays on the composition and thermal behavior, besides proving the presence of chitosan and PCL in the sponge, indicated a good thermal stability, enabling them to be used in the temperatures found in the oral cavity. In the Zeta Potential analysis, a cationic behavior of characteristic of chitosan, which in the future will benefit from contact with the various components present in the oral cavity that have anionic character.