Síntese, caracterização, avaliações in silico e biológica do tereftalato de bis[(2-OXO-2-(FENILAMINA)] de etila usando garrafas pet como matéria-prima

Abstract

The use of new methodologies and raw materials in the procurement of new drugs has become a constant in research centers around the world. Produce more effective and less toxic products has became the ambition of many scientists and to be able to develop a production that generate less impact to the environment is indispensable. In the view of reducing impacts caused by the numbers of PET bottles discarded in undue places, it was used as raw material to obtain the terephthalic acid through a depolymerization reaction. The present work reports the synthesis and characterization of the compound derived from this acid which was obtained in three steps: i) the depolymerization reaction of PET, ii) the acetylation of the aromatic amines and finally iii) obtaining the final compound through A substitution of potassium terephthalate with 2-chloro-N-phenylacetamide. The synthesis has shown to be simple and in good yields, intermediate and final compounds were characterized by IR, 1H and 13 C NMR spectroscopic techniques. An in silico investigation and antimicrobial evaluation of the compounds were carried out, where they showed an excellent antifungal activity, inhibiting six of the six Candida species with MIC in the range of 256 for 2-chloro-N-phenylacetamide and 512 for potassium terephthalate compounds and bis (2-oxo-2-(phenylamine)) ethyl terephthalate.