Potencial anti-inflamatório e perfil antioxidante do eugenol: uma revisão

Abstract

The bioactive compounds found in foods and medicinal plants are attractive molecules for the development of new drugs with action against various diseases, such as those associated with inflammatory processes, commonly related to oxidative stress. Many of these compounds have an inhibitory effect on oxidative stress and inflammatory response, and can contribute in a preventive way to improve the quality of life through the use of a diet rich in these compounds. Eugenol is a natural compound that has several pharmacological activities, such as anti-inflammatory, antitumor, antibacterial, anesthetic, action on redox status and applications in the food and pharmaceutical industry. Considering the importance of this compound, the present review aimed to discuss its anti-inflammatory and antioxidant properties, demonstrating its mechanisms of action and therapeutic potential for the treatment of inflammatory diseases. Thus, a review of the literature, using scientific articles available in the PubMed database, published between 2008 and 2018, on the anti-inflammatory and antioxidant activity of eugenol was carried out. Therefore, this review demonstrates that eugenol exerts a beneficial action on oxidative stress through the inhibition of enzymes and oxidative processes, which is related to the anti-inflammatory profile of this compound.