Fibrose hepática congênita associada à ascite em um bezerro nelore (Bos primigenius indicus)

Abstract

Congenital hepatic fibrosis (CHF) is an autosomal recessive malformation characterized by variable degree of fibrosis and bile duct proliferation, mainly described in people and rarely reported in European cattle. In addition to liver fibrosis, in calves this syndrome has been associated with ascites and subcutaneous edema. This paper describes the pathological 12 findings of the first report of CHF in a Nelore bovine fetus. A stillborn calf was removed by cesarean section due to dystocia. At necropsy, characteristic changes of CHF were observed, such as a large increase in abdominal volume associated with hepatic fibrosis and marked subcutaneous edema. Histological examination of liver revealed periportal and portoportal islands of fibrosis separating the parenchyma into nodules of variable sizes and containing numerous abnormally shaped bile ducts.