Dexmedetomidina intranasal em gatos: efeitos sistêmicos e tempo de ação da dose de 10 mcg/kg.

Abstract

To assess sedation, time of action and effects on heart rate (HR), respiratory rate (RR), rectal temperature (RT), systolic blood pressure (SBP), intraocular pressure, glycemia, hematocrit (HT) and splenic diameter, eight healthy cats were treated with dexmedetomidine at a dose of 10 mcg/kg intranasally. The parameters were measured at baseline (M0) and every 15 minutes until the animal presented values around 80% of basal glucose or reached time 120. Sedation was measured by response to manipulation (0 none, 1 minimum, 2 moderate, 3 intense), head position (0 lowered, 1 raised), response to sound stimulus (0 unresponsive, 1 slightly responsive, 2 alert) and decubitus (0 lateral, 1 sternal, 2 quadrupedal). The lowest RR (44 mpm) and HR (132bpm) values were observed in M45, but only HR differed statistically from M0 at this time; SBP decreased over time by 60 minutes; temperature and intraocular pressure remained constant; glycemia presented its highest value in M60 (149 mg / dL); lowest hematocrit value (34.25%) and largest splenic diameter (1.04 cm) correlated with peak at M30; handling response differed from M0 for 75 minutes. It was concluded that dexmedetomidine at a dose of 0.01 mcg/kg intranasally promoted satisfactory sedation for 75 minutes in healthy cats, between one and five years, without marked changes in the evaluated parameters.