Uso do doppler transcraniano na prevenção do acidente vascular encefálico na doença falciforme

Abstract

Introduction: the denomination sickle cell disease (DF), comprises a group of inherited disorders characterized by the presence of hemoglobin S, in homozygosis or in combination with other abnormal hemoglobins, generating symptomatic conditions characterized by chronic hemolysis and vasocclusive phenomena in the circulation, resulting in painful crises, vessel occlusion of organs causing dysfunction, as well as manifestations such as priapism, splenic sequestration crises, acute chest syndrome and stroke. Considering that the CVA is an event with a high incidence, varying from 8 to 11% and with a great impact on the morbidity and mortality of sickle cell disease, a strategy to prevent this event is necessary. Objectives: this study aims to analyze the outpatient use of transcranial doppler in primary prevention of stroke in clildren and adolescents with sickle cell disease, through a literaturte review. Material and methods: this work was elaborated from a narrative review of the literature through research in bibliographic sources of lilacs, cochrane and medline databases using as descriptors “sickle cell disease” and “stroke” and “transcranial doppler ultrasonography” and “child”. 341 articles were identified and after reading the titles, 82 articles were selected to read the abstract and those that did not relate to the purpose of this study were excluded. After reading the abstracts, 12 articles were selected that met the initially proposed criteria and were read in full. Results and conclusion: most of the selected articles were studies of randomized clinical trials, and validated the high sensitivity and specificity of the use of transcranial doppler as a predictive risk factor for stroke in children and adolescents with sickle cell disease and, therefore, for being performed in an outpatient clinic, non-invasive and with extremely high sensitivity and specificity, it has a very important aspect for risk monitoring in this group of patients.