FATORES DE RISCO ASSOCIADOS AO AUMENTO DE MORTALIDADE EM PACIENTES SÉPTICOS INTERNADOS EM UNIDADE DE TERAPIA INTENSIVA

Abstract

Sepsis is a potentially fatal clinical syndrome characterized by an abnormal response to infection associated with organ dysfunction. It is a relevant cause of admission to intensive care units (ICU) and related to increased morbidity and mortality rates. This study aimed to evaluate the epidemiological profile of adult patients in the ICU of the Hospital Universitário Lauro Wanderley (HULW) in the city of João Pessoa (PB) to determine the risk factors associated with increased mortality in patients with sepsis. This was a retrospective, observational study that analyzed notification forms from the Hospital Infection Control Committee (CCIH) of HULW referring to the period from January 2016 to December 2019. The mortality risk analysis was performed in two parts. Initially, Pearson's chi-square test was used to determine the association between categorical variables. Then, only variables with p-values < 0.05 were included in the final logistic regression model to neutralize the effects of confounding variables. The findings of this study suggest that septic shock and the use of IMV and CVC are the factors that deserve the most attention in patients with sepsis. However, among them, IMV is the main risk factor for death in patients with sepsis in the ICU. Variables such as gender, age, and comorbidities did not inflate the mortality rate of the patients studied.