ANÁLISE DO EIXO TIREOIDIANO E DO PERFIL BIOQUÍMICO EM CRIANÇAS COM EXCESSO DE PESO

Abstract

There is a current discussion in the literature about the relationship between excess weight and thyroid hormones. The increased concentration of thyroid hormones has been associated with a physiological adaptation to favor weight loss in overweight individuals. The aim of this study is to analyze the association between plasma concentrations of TSH, T3L and T4L and the biochemical profile in control and overweight children. For this, children of both sexes, aged 8 to 15 years, were allocated according to nutritional status in the control (C, n=28, 14 boys and 14 girls) and overweight (SE, n=22, 11 boys and 11 girls) groups. girls). Plasma concentrations of TSH (C = 1.78 ± 0.98; EP = 1.60 ± 0.60), T3L (C = 5.22 ± 0.86; EP = 5.49 ± 0.79), T4L (C = 12.41 ± 1.11; EP = 12.7 ± 2.21), insulin (C = 7.38 ± 2.97; EP = 12.48 ± 3.82), leptin (C = 5.62 ± 5.05; EP = 37.65 ± 32.24), glucose (C = 85.05 ± 7.31; EP = 81.86 ± 6.93), total cholesterol (C = 116.77 ± 29.62; EP = 149.12 ± 33.80), HDL (C = 34.42 ± 11.02; EP = 35.74 ± 13.05), LDL (C = 46.05 ± 22.20 ; EP = 70.13 ± 21.38) and triglycerides (C = 77.30 ± 32.91; EP = 104.94 ± 52.94) were evaluated. Children in the overweight group had increased concentrations of LDL (p < 0.001), triglycerides (p = 0.028), leptin (p < 0.001) and insulin (p < 0.001). No differences were found between TSH, T3L and T4L between the groups. The overweight group did not present concentrations of TSH, T4L and T3L different from the control group.