Tumor cutâneo de bainha de nervo periférico em peixe kinguio (Carassius auratus) - Relato de caso

Abstract

Soft tissue spindle cell tumors (TCFTMs) comprise a heterogeneous group of mesenchymal tissue neoplasms that may present similar histopathological changes, such as peripheral nerve sheath tumor (TBNP) and perivascular wall tumor (TPP). However, classifying them is not always possible when relying exclusively on cytological examinations and histopathological findings. This work aimed to report a case of cutaneous tumor of the peripheral nerve sheath in a kingfish (Carassius auratus). A C. auratus, 1 year old, weighing 75 g, was sent to the Veterinary Hospital of the Federal University of Paraíba presenting an orange skin tumor measuring approximately 2 cm, slightly elevated above the skin surface, with a friable, soft and multilobulated texture. in the dorsal region of the fin and on the right lateral region of the body, with growth for approximately six months. A surgical procedure was performed to remove the mass. The excised nodules were subjected to cytological, histopathological and immunohistochemical evaluation. Histopathology revealed pleomorphic neoplastic spindle cells arranged in a storiform pattern or palisades typical of the Antoni A and Antoni B pattern. Immunohistochemistry showed diffuse cytoplasmic immunoreactivity of the neoplastic cells to the S100 protein and negativity to the PAFG protein (Glial Fibrillar Acid Protein). Findings compatible with cutaneous peripheral nerve sheath tumor were found on histopathology and immunohistochemistry. This is the first report of a cutaneous peripheral nerve sheath tumor in C. auratus described in Brazil. For confirmatory diagnosis, histopathology and immunohistochemistry are used.