Níveis de magnésio intracelular e cerebral, seus efeitos na cognição e os benefícios da suplementação de magnésio l-treonato: uma revisão integrativa

Abstract

Magnesium ranks among the body's most prevalent essential minerals. While conventional magnesium supplements often present challenges in bioavailability, a novel magnesium compound, magnesium L-threonate (Magtein®), was found to be notably effective in raising magnesium levels including within cerebral tissues and neuronal structures. More recent findings about the role of magnesium in mental health suggest that low concentrations of magnesium in the brain can lead to mental disorders and cognitive impairment. This study aimed to analyze some of the latest research on the matter and integrate the obtained results to furnish an overall more in-depth understanding of magnesium's implications for cognitive and mental well-being and the actual advantage of using magnesium L-threonate as a better alternative for supplementation. A search was carried out in the PubMed and Google Scholar databases using the keywords on the subject, with a focus on literature published within the preceding five years. Exclusion criteria encompassed prior reviews, cohort studies, in vitro investigations, and articles lacking relevance to the specific objectives of this review. Subsequent to the application of these criteria and careful examination of retrieved articles, a total of eleven studies were deemed eligible for inclusion. Collectively, these studies underscored the notable influence of magnesium on cognitive function, with eight investigations establishing a significant association between the mineral and short-term memory, while four studies identified effects on anxiety and depression-like behaviors. Moreover, eight studies highlight the potential benefits associated with magnesium L-threonate supplementation to ameliorate these symptoms.