ANÁLISE DOS PERFIS EPIDEMIOLÓGICO E HISTOPATOLÓGICO DE PACIENTES PORTADORAS DE CÂNCER DE MAMA TRIPLO NEGATIVO EM HOSPITAL DE REFERÊNCIA NA PARAÍBA

Abstract

Based on the incorporation of technologies and studies aimed at breast cancer over the years, it is now possible to identify several subtypes of the disease, which end up influencing the treatment and prognosis of patients. Among these subtypes, the immunohistochemichal composition of the triple negative (TN), due to the absence of hormone and HER2 receptors, is a challenge because it has fewer therapeutic targets, in addition to a differentiated natural history and epidemiology. 220 patients attended from 2015 to 2020 at the Napoleão Laureano hospital, in Paraíba,, were included for the analysis of anatomopathological and epidemiological characteristics. Among them, 25 had the TN subtype. The variables age, KI-67 expression, family history of cancer, lymphocytic tumor infiltrate (TIL) and clinical staging were used to compare the subtype in relation to the others, the latter being divided into stages I and II or III and IV. For the analysis of age at diagnosis, the non-parametric Kruskal-Wallis test was used to compare the mean ranks between the subtypes, with a statistically significant difference (p<0.05) between the TN subtype for older ages. As for the other variables, no differences were observed between the subtypes based on the Odds Ratio analysis and the logistic regression model for risk factors, except for the expression of KI-67, which is higher in the TN subtype compared to the luminal subtypes, which may indicate greater cell proliferation. Larger studies should be undertaken to better stratify the profile of the neoplasm that most affects women worldwide, especially with the worst prognosis subtype, the triple negative.