Identificação de drogas ilícitas em fios de cabelo através da técnica Maldi: uma revisão na literatura

Abstract

Illicit drugs such as opiates, marijuana, cocaine, amphetamines and ecstasy are non- legalized substances that have properties that alter the Central Nervous System (CNS), which can be detected in biological samples after consumption. Blood and urine are biological materials that are commonly used to identify the consumption of substances, but they have a short detection window. Another matrix is hair fibers, which have a large detection window and allow obtaining history related to the use of illicit substances. The most commonly used conventional methods for analyzing hair fibers are Gas Chromatography (GC) and Liquid Chromatography (LC), however, there are techniques that make it possible to obtain results in a faster and simpler way when compared to these techniques, as is the case Matrix-Assisted Laser Desorption Ionization (MALDI). This technique is responsible for desorption and ionization of the molecule, to later identify the ion formed and can be coupled to different types of analyzers and detectors. In this review, three databases were used, namely PUBMED, WILEY and SCIENCE DIRECT to search for articles. The objective of this work is to present MALDI as a promising new technique for identifying illicit drugs in hair strands, which, when compared with conventional methods already used in clinical practice, present better sensitivity in identifying substances, reducing the time to obtain results. results and preparation of the sample to be analyzed is simpler.