A Influência da desregulação da crononutrição no desenvolvimento de doenças crônicas não transmissíveis

Abstract

The prevalence of non-communicable chronic diseases has increased significantly, and adequate nutrition is one of the main modifiable factors that helps in prevention and treatment. In this sense, it becomes extremely relevant to elucidate this relationship and seek new effective approaches that present ideal metabolic outcomes for the body's homeostasis. Among these approaches, chrononutrition stands out, which deals with the study of the relationship between the circadian rhythm and meal times. The objective of the research was to evaluate the metabolic mechanisms that are affected by the dysregulation of the circadian rhythm, understanding how food can influence this rhythm, and to elucidate the strategies in the area of chrononutrition that promoted an improvement in the metabolic profile with consequent intervention in the development of non-communicable chronic diseases. transmissible. This work is a Literature Review carried out through searches of scientific articles between the years 2012 to 2022 in the main databases (Pubmed, Science Direct, Portal Periódico Capes, Scielo, Medline and Google Scholar). In total, 70 scientific articles on the subject were obtained, and after complete reading, only 21 articles were considered for the review. As a result, different studies were analyzed that addressed the chrononutrition strategy in the main non-transmissible chronic diseases and how circadian dysregulation can affect their development. In view of this, it was possible to observe that a higher daily caloric intake during the day and lower at night proved to be favorable in the prevention and treatment of Type II Diabetes Mellitus, Obesity, Systemic Arterial Hypertension and Cancer, improving the metabolic profile. It is therefore concluded that it is pertinent to deepen knowledge in this area in order to enable the development of more adequate and innovative nutritional interventions.