Avaliação de colutório contendo sistema de liberação controlada de flúor: estudo clínico Randomizado

Abstract

Objective: To evaluate in vivo the effect of mouthwash with controlled-release system (CRS) for the delivery of fluoride (F) on the retention of F in dental biofilm and saliva. Material and methods: The mouthwashes used in the study were: Placebo (without F); A (225 ppm, all free sodium fluoride); B (225 ppm, 50% free sodium fluoride + 50% CRS-sodium fluoride); C (225 ppm all CRS-sodium fluoride).

A randomized, triple-blind crossover clinical trial study was performed with twenty- one residents of a city without water fluoridation programe. After weekly use of

mouthwashes, samples of biofilm and saliva were collected 1h and 12h after the last rinse for biofilm and, 0 to 60 minutes and 12 hours for saliva. The concentrations of F in saliva and biofilm were analyzed by specific electrode through diffusion technique facilitated by hexamethyldisiloxane (HMDS). Data were analyzed by repeated measures ANOVA followed by the Bonferroni test (p<0.05). Area under the curve (AUC) was calculated for saliva data. Results: For AUC0-60min the values were: A (162.2) > B (138.3) > C (129.6) > Placebo (4.80). In biofilm, mouthwash B presented highest value of F concentration (ug/kg) for 1h (4.886) and A (5.038) for 12h. Conclusion: It can be concluded that the CRS for delivery of fluoride tested in this study provides a different pattern of fluoride delivery compared to free fluoride formulations and may present a beneficial effect since it has the potential for increasing substantivity of F in the oral cavity. Clinical relevance: Mouthwashes with controlled fluoride release systems can be a good post-brushing product to increase the levels of fluoride in the oral cavity.