COMPLEXO GRANULOMA EOSINOFÍLICO EM CÃES E GATOS.

Abstract

The eosinophilic granuloma complex is a syndrome composed of three diseases: eosinophilic granuloma, eosinophilic plaque and indolent ulcer. In dogs this complex is infrequent, when present the most observed form is eosinophilic granuloma. The granuloma appears in the form of a firm, rosy and squamous elevation, appear in the posterior region of the pelvic limbs, in the face and in the buccal cavity, coursing without pruritus. The eosinophilic plaque is found in the form of an erythematous, erosive and ulcerated alopecia plate in the abdomen, inguinal region, internal or external part of the pelvic extremities, neck and interdigital spaces, with pruritus. The etiology of this disease is still unknown, but the possible causes can be allergic, atopic, hypersensitive, viral, bacterial, parasitic, autoimmune, genetic or even idiopathic. The diagnosis of the lesions is made through the history, clinical examination, cytology and, mainly, by histopathology. Treatment is based on corticotherapy, but additional methods, such as antibiotics, may be used. The present study reports four cases of eosinophilic granuloma complex, three cases in cats (two eosinophilic plaques and one oral eosinophilic granuloma) and one case of eosinophilic granuloma in a canine.. The diagnosis was confirmed by histopathology. The diagnosis of the eosinophilic granuloma complex was based on the clinical findings, the hemogram score and the histopathological findings. In cases of eosinophilic plaque the clinical findings consisted of whitish coloring on the epidermis, corresponding to the eosinophilic aggregates that delimit the collagen fibers that were partially ruptured. Oral eosinophilic granuloma occurred nodularly. Histologically, the epithelium was spongy, due to the separation of the epithelial cells below the mucosa. Numerous eosinophils, macrophages, lymphocytes and some plasma cells were observed in addition to the Splendore-Hoeppli phenomenon. All cases responded to corticosteroids. It was concluded that the eosinophilic granuloma complex comprises a group of cutaneous and mucocutaneous lesions more common in domestic felines than in canines.