Modulação da resistência a drogas por óleos essenciais em linhagens de Staphylococcus aureus

Abstract

Bacterial resistance to drugs can happen due to different mechanisms. Among these, efflux bombs highlights and these structures are integrant part of membran cell. The increasing incidence of resistant bacteria has undermined the therapeutic value of available antibacterials, creating the necessity, increasingly, the search for alternatives that can reverse or decrease the resistance, as the search for inhibitors of resistance mechanisms. In order to resolve this problem, products from plants (extracts, essencial oils and phytoconstituents) rise as rich research source on drug resistance modulators , that is, drugs that increase antibiotics activity or even revert bacterial resistance. In this work, we investigated how modifiers of antibiotic activity act in Staphylococcus aureus strains that are efflux bombs carriers. The essencial oils used were extracted from Rosmarinus officinalis L., Illicium verum Hook., Cananga odorata, Eucalytus globulus, Pelargonium graveolens , Citrus paradisi, Cymbopogon flexuosus, Melaleuca alternifolia, Mentha Spicata, Origanum vulgare, Cymbopogon Martini, and their major constituents used were 1,8-cineol, Anetol, Trans-Caryophyllene, Citronelol, Limoneno, Citral, Terpenen-4-ol, L-carvone, Carvacrol and Geraniol. Our results show that the natural products evaluated, in general, present significant antibacterial activity, and probably they operate as modifiers of antibiotic activity, strains through reduction of CIM of tested antibiotics (tetracycline, erythromycin and norfloxacin) from 2 to16 fold. The results show that natural products from plants are in fact potential antibiotics adjuvants.