Estudos preliminares do efeito cicatrizante do sucralfato utilizado topicamente em úlceras orais de gatos

Abstract

The oral cavity represents the entry of the digestive system and any abnormality, the disease itself or the region, the ability to deal with adverse effects such as decreased water and food intake, reduced nutritional use, weight loss, decreased quality of life. In cats, there are important systemic diseases that lead to the emergence of oral ulcers, such as a chronic kidney disease, a feline viral immunodeficiency (FIV), a leukemic viral feline (FeLV), a calicivirus, a gingiva-stomatita-pharyngitis and as periodontitis, Treatment is necessary in an efficient and rapid way so that the animal can recover from an animal quality of life. Sucralfate is a cytoprotective drug routinely used in peptic and duodenal ulcers, as is the case of studies that point to the treatment of burns and mucositis with the association of radiotherapy. The animals with oral ulcers treated at the Veterinary Hospital of the UFPB were treated separately in two groups, where the group received treatment based on conventional treatment criteria and topics. The images were photographed on days D0, D7, D14 and analyzed using Imagej 1.52a software, measuring the areas of ulcers in cm² on the pre-established days. They were subsequently calculated as indicators of ulcer regression index and treatment time for comparison. A 22% higher regression index was observed in the sucralfate treated group and a lower 4-day regression time, demonstrating acceleration in the cicatricial process. Sucralfate topic decreased the healing time of oral ulcers of various origins in cats, being easy to apply. However, additional studies with the experimental groups and the histopathological analysis of the lesions are necessary.