Leiomiossarcoma uterino, feocromocitoma em adrenal e adenocarcinoma pulmonar concomitantes em um cão.

Abstract

Leiomyosarcoma is a malignant mesenchymal neoplasm of smooth muscle of the uterus. Pheochromocytoma is a neoplasm of neuroectodermal origin that arises in the adrenal medulla. Adenocarcinomas are pulmonary tumors and can be classified as epithelial or mesenchymal, being differentiated according to malignancy and histological type. The three tumors are not commonly diagnosed neoplasms in dogs. Concomitant occurrence of these tumors in the same animal is extremely rare. The aim of this article is to report the case of a female dog with these three neoplasms - diagnosed at the UFPB Veterinary Hospital - and to describe the histopathology of the tumors. After anamnesis, physical exams, laboratory exams and imaging exams, the animal underwent emergency ovariohysterectomy surgery. Due to several factors of tumor involvement and possible metastases, it was decided to perform euthanasia. The animal was sent to the Veterinary Pathology Laboratory (LPV), where a necropsy was performed, the tissues were collected and the routine processing was performed. It was possible to verify the proliferation of neoplastic cells in several tissues. Macroscopic and microscopic evaluation of the following organs: lung, uterus and adrenals revealed alterations worthy of primary tumors, such as loss of histological architecture of the organs, as well as cells with a high degree of anisocytosis / anisocariosis and variable mitosis rates. In addition to these, changes were also found in other tissues such as kidneys, liver and spleen; In the latter, metastasis from the adrenal tumor was identified. The definitive diagnosis was possible through necropsy, where the organs were evaluated using the histopathological analysis method.