Síntese e avaliação biológica do (±)4-O-Demetilkadsurenina M, e seus análogos

Abstract

An important class of biologically active natural molecules are lignoids, molecules formed exclusively by the coupling of phenylpropanic groups (C6-C3) n, where 'n' is restricted to a few units, 1,2,3 etc. Examples of lignoids include lignans, neolignans, allolignans, oligolignoids and heterolignoids. This paper presents an approach to neolignans that together with lignans represent 90% of the lignoids described in the literature. Neolignans have a huge structural diversity, nature itself offers us a very wide variety of these compounds, besides, from a chemical point of view, and several neolignans have already been used as starting material for the synthesis of derivatives of natural products with various purposes, such as optimizing product activity and studying the structure-activity relationship. These molecules also have numerous pharmacological activities described in the literature, such as antitumor, antibacterial, antimicobacterial, trypanosomicide, schistosomicide, leishimanicide, etc. activities. There are several ways to synthesize these types of compounds in the laboratory, such as oxidative couplings obtained through FeCl3, Ag2O, peroxities, among others. Thus, the objective of this study was to synthesize neolignan substances for the biological evaluation of them in human tumor cells HL-60 (acute promyelocytic leukemia), HCT-116 (human colorectal carcinoma), MCF-7 (human mammary adenocarcinoma). , K562 (chronic myeloid leukemia) and non-tumor lineage L929 (murine fibroblast), as well as bacterial strains Escherichia Coli UFPEDA224, Staphylococcus aureus UFPEDA02 and Pseudomonas aeruginosa UFPEDA416.