Avaliação dos mecanismos de toxicidade da proteína antifúngica Mo-CBP3 em embriões de peixe-zebra (Danio rerio)

Abstract

Mo-CBP3 is an antifungal protein isolated from Moringa oleifera seeds, which is considered a candidate for the development of transgenic crops to confer resistance against phytopathogenic fungi. However, previous studies have shown that this protein is toxic to zebrafish (Danio rerio) embryos, acting, in part, through the imbalance of reactive oxygen species and neurotoxicity . Therefore, it is necessary to advance in the understanding of the toxicity mechanisms of Mo-CBP3 and, thus, provide subsidies for its use as a biotechnological tool