Colangiocarcinoma intra-hepático em um camaleão-pantera (Furcifer pardalis): relato de caso

Abstract

Cholangiocarcinoma is a primary malignant neoplasm of the liver, triggered by changes in the growth of epithelial cells of the bile ducts that affect domestic and wild animals. We report a case of cholangiocarcinoma in a panther chameleon (Furcifer pardalis) necropsied at the La boratory of Veterinary Histopathology of the Federal University of Paraíba, Areia-PB. The an imal was hospitalized with a history of anorexia and wasting and died shortly after. Necropsy was performed using an adapted conventional technique and the organs were collected for fur ther processing and preparation of slides. The significant macroscopic findings were liver with increased size and shiny surface, with the presence of a focal circular intrahepatic nodule and the presence of discrete darkened spots; the kidney, presented with an adhered caseous structure and the gallbladder was full. Histopathological findings revealed liver with delimited areas of simple columnar cell proliferation, rounded cytoplasm, characterized as epithelial cells of bile ducts, with dense stroma and areas of inflammatory infiltrate. The caseous nodule had focal areas of necrosis interspersed with aggregates of bacteria. To knowledge of the authors, this is the first report of cholangiocarcinoma in a panther chameleon. Which can be diagnosed from the anatomopathological and immunohistochemical findings.