Características fitoquímicas e biológicas de cissampelos sympodialis eichler (menispermaceae) – uma revisão bibliográfica

Abstract

The species Cissampelos sympodialis Eichler, popularly known as "milona", "jariinha" and "orelha-de-onça", the plant has been used for decades by the population of Paraíba for the treatment of inflammatory disorders, especially those that affect the airways, with highlight for its effective action in the treatment of allergic asthma. Its therapeutic activity was supported by several studies carried out for nearly thirty years. C. sympodialis is not yet found in official herbal medicine compendiums in Brazil, and there is no drug developed with the plant or its derivatives. For this purpose, the databases Web of Science, Scopus, Science Direct, Pubmed, Scielo and Lilacs were used, using the descriptor Cissampelos sympodialis. The search performed generated a quantitative 254 records, which were screened, and went through the eligibility and inclusion phases, with 60 scientific articles being chosen for the construction of this work. The results show that the species has a richness of alkaloid components, with 10 molecules already characterized, highlighting the alkaloid Warifteína, considered a biological marker of the species. Added to this, numerous biological activities have been described, in which the anti-inflammatory and anti-allergic activities are already well characterized, supporting its use by the population for respiratory diseases such as allergic rhinitis and asthma. Even with high therapeutic potential, the species is still little known by the population of Paraíba, with a need to spread knowledge about the plant, established as a symbol plant of the state of Paraíba. With this in mind, we developed an information leaflet so that it can be transferred to public health agencies for distribution in primary care units, as a way to contribute to popular knowledge of the advantages of its use. We also created a front for the dissemination of the species together with institutional partners for the dissemination of the species through social networks, expanding its reach to the public. Based on the findings of this work, we therefore consider that C. sympodialis is a promising species for the development of a new drug, and that the strengthening of strategies that contribute to its knowledge can strengthen local herbal medicine and comprehensive health care for several individuals.