Diabetes Mellitus não aumenta mortalidade intra-hospitalar em pacientes internados por COVID-19: estudo de coorte

Abstract

FONSECA, L.C. Diabetes mellitus doesn’t increase in-hospital mortality in patients admitted with COVID-19: a cohort study. 2021. Trabalho de Conclusão de Curso (Bacharel) – Centro de Ciências Médicas, Universidade Federal da Paraíba, João Pessoa-PB, 2021. Objectives: Faced with the pandemic caused by SARS-CoV-2, it is necessary to understand its risk factors. The aim of this study is to acess the risk of mortality and severity of diabetics patients hospitalized with COVID-19 in a nosocomial unit. Materials and methods: This is a prospective cohort study, in which we followed 236 patients admitted with COVID-19 to a referral hospital in João Pessoa, Paraíba, Brazil, between June and August of 2020. We dosed some biochemical markers, with an emphasis on glycated hemoglobin, and analyzed its relationship with mortality. We separated patients into three groups: DM (previous diagnosis of diabetes); new DM (discovered on admission) and non-DM (without diabetes). To perform the statistical tests, we used GraphPad Prism program. The level of significance accepted was p < 0,05. Results: Of the 236 patients, 106 (44,9%) were from the DM group; 98 (41,5%) belonged to the new DM, and 32 (13,5%) remained in the non-DM group. In Spearman's correlation, glycated hemoglobin showed an inverse relationship with DHL, TGP and TGO, in addition to a weak correlation with other inflammatory markers. In the Mann-Whitney test, we found no correlation between mortality and diabetes and coronavirus infection. By analyzing the chi square test, we observed no significant difference in in-hospital mortality from COVID-19 between the three groups (non-DM, new DM and DM). Conclusion: There is no increase in in-hospital mortality in diabetic patients admitted with COVID-19. Futhermore, glycated hemoglobin is a poor prognostic marker for coronavirus.