Análise de custo da produção de amoxicilina via rota enzimática

Abstract

The low production of Active Pharmaceutical Inputs (IFAs) of the Brazilian industry is an unfavorable aspect for the economy of the country, which has a high index of consumption of medicines, especially antibiotics. This adverse situation of the national conjuncture constitutes an opportunity for study and development in order to solve the state of dependence of the foreign industry. Thus, the objective of this work was to carry out an economic viability analysis of the acquisition of amoxicillin via the enzymatic route, verifying the possibility of a national industry of this input. For the cost analysis, four concentrations of the PGA enzyme were considered for reaction catalysis. The production occurred at 25 ° C, atmospheric pressure and neutral pH. The reaction is solubilized by water. Through simulation using the mathematical software Origin and Matlab, a small industry was designed for the production of 8460 kg of amoxicillin. Then, the cost analysis of the production of amoxicillin and the indebtedness for the construction of the plant was also carried out by simulation. The cost benefit analysis was satisfactory, confirming the investment feasibility of the production of amoxicillin in the conjuncture.