Status nutricional de vitamina D, parâmetros bioquímicos, inflamatórios e força muscular em indivíduos com Covid-19

Abstract

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov-2) causes Coronavirus Disease (COVID-19) which is characterized by an inflammatory process, due to an increase in the release of cytokines, such as interleukin-6, in addition to hypoalbuminemia. On the other hand, vitamin D can help control the inflammatory process, however, this disease still leaves sequelae such as fatigue or muscle weakness. In this context, this research aimed to evaluate the relationship of serum vitamin D levels with the inflammatory and biochemical profile in individuals with COVID-19 and muscle strength in individuals after COVID-19. This research is characterized by being a cross-sectional study carried out in sequential sections between the months of June and August 2020. Individuals over 18 years of age, who were hospitalized with COVID-19 in the referenced network of the metropolitan region of João, participated in the study. Pessoa, the Dom José Maria Pires Metropolitan Hospital. Data collection was divided into two sections, the first of which was performed with 253 individuals, and consisted of sample characterization and biochemical analysis (calcium, PTH, albumin, liver and kidney function, blood count, total cholesterol and fractions, glycated hemoglobin and blood glucose). fasting), inflammatory parameters (Interleukin-6 and Neutrophil-Lymphocyte Ratio) and serum levels of vitamin D. COVID-19. Data were expressed as percentage, mean and standard deviation. To assess the normality of the data, the Kolmogorov-Smirnnov test was performed (p<0.05). For correlations, Pearson's correlation test was applied, considering p<0.05 as a reference for significant differences. According to the results, it was possible to observe a higher prevalence of male individuals (55.33%), with a mean age of 61.45±15.52 years, 55.33% of whom were elderly. The mean serum levels of vitamin D were 30.41±17.94ng/mL. No relationships were observed between vitamin D, PTH and calcium. There was also a negative correlation between IL-6 and vitamin D levels, in addition, hypovitaminosis D is associated with female sex (p=0.009), and eosinopenia was correlated with lower serum levels of vitamin D. Additionally, there is a correlation of total cholesterol, LDL-c and albumin with a poor prognosis of COVID-19. Data regarding patient care in the second cut showed that 78.9% (n= 30) had low muscle strength based on Hand Grip Strength (HGS). In addition, HGS was significantly lower in elderly subjects and correlations were observed between HGS and age, muscle mass and fat mass.